2-cyclohexyl-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine
1255580-76-7
509.7
C30H47N5O2
DMSO
-20°C
UNC0638 is a cell-permeable, potent G9a HMTase inhibitor, exhibiting an IC50 value of 50 value of 19 nM, but is more than 10,000-fold selective against SET7/9 (a H3K4 HMTase), SET8 (a H4K20 HMTase), PRMT3, and SUV39H2. UNC0638 inhibits H3K9 dimethylation in MDA-MB231 cells with an IC50 value of 81 nM and demonstrates favorable separation of functional and toxic effect.
0.1 lbs
Research or further manufacturing use only, not for food or drug use.
